Immunology (Curso 2023/2024)
Curso 1. Asignatura Primer cuatrimestre. Formación básica. 6 Créditos
Profesores
Isabel Olazabal Olarreaga - Coordinador
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Alberto Benito Martín
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María Inmaculada Domínguez Mozo
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Vanesa Esteban Vázquez
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Ana Martínez García
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Antonio Muñoz Callejas
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Domenico Rosace
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Objetivos
The student will recognize the different components of the immune system
The student will combine and integrate the principal components of the immune system to learn the different immune responses: innate and adaptive
The student will identify those components of the immune system with biomedical applications in diagnosis and immunotherapyRequisitos previos
No se requieren pero es necesario cursar Biology al mismo tiempoCompetencias
Conocimientos
RCG2. Aprender la comunicación oral y escrita en la lengua nativa y en lengua extranjera
RCG13. Asumir la sostenibilidad mediante la sensibilidad hacia temas medioambientales.
RCE1. Comprender y reconocer la estructura y función normal del cuerpo humano, a nivel biomolecular, celular, tisular, orgánico y de sistemas, en las distintas etapas de la vida.
RCE6. Comprender y reconocer los agentes causantes y factores de riesgo que determinan los estados de salud y el desarrollo de la enfermedad.
RCE7. Reconocer y clasificar el microbioma y los microorganismos patógenos y comprender su papel en el tratamiento y en la génesis de las enfermedades respectivamente.
RCE9. Comprender y relacionar los diferentes componentes del sistema inmune y su papel en patología
Habilidades y destrezas
RCG4. Desarrollar habilidades en las relaciones interpersonales y trabajo en equipo, interdisciplinar e internacional
RCE10. Comprender la estructura y función de las biomoléculas para su aplicación como diana terapéutica, y como ayuda al tratamiento y diagnóstico
Competencias
RCG1. Desarrollar la capacidad de análisis y síntesis, y de organización y planificación.
RCG3. Desarrollar la gestión de la información.
RCG5. Adquirir la capacidad para resolución de problemas y toma de decisiones.
RCG6. Adquirir la capacidad del razonamiento crítico.
RCG7. Generar propuestas creativas, adquirir actitudes de liderazgo, iniciativa y espíritu emprendedor.
RCG8. Desarrollar estrategias de aprendizaje autónomo.
RCG9. Saber adaptarse a nuevas situaciones.
RCG10. Adquirir un compromiso ético.
RCE2. Relacionar la función en los diferentes niveles de organización del cuerpo humano.Resultados de aprendizaje
To recognize the organographic, cellular, and molecular elements of the immune system
To combine the principal components of the immune system and the different immune responses: innate and adaptive
To identify those components of the immune system with biomedical applications in diagnosis and immunotherapyDescripción de los contenidos
1. Objectives, organs, tissue, cellular and molecular components of the innate immune system. PAMP. Mechanisms of Innate immunity. Immflamation and anti-immflamatory drugs.
2. Origin and maturation of cells of the innate and adaptive immune system. Haematopoiesis and stem cells
3. Objectives, secondary organs, tissue, cellular and molecular components of the adaptive immune system. Lymphocytes, antibodies and vaccines
4. Antigen processing and presentation to T cells. Dendritic cells and therapy. HLA molecules, polymorphisms, and their role in transplantation.
5. Antigen receptors: BCR and TCR. Specificity and diversity. BCR and TCR genes and genetic reorganization. B cell and T cell maturation. Learning tolerance
6. Activation of T lymphocytes. Co-stimulatory molecules and biomedical applications. T cell differentiation. Helper and cytotoxic T cells effector responses.
7. Activation of B cells. Collaboration between T and B cells. Generation of memory and its biomedical applications. Effector response: antibodies. Diagnosis, treatment and immunotherapy
8. Immune response during reinfection. Memory response. Vaccines
9. Lymphocyte tolerance. Regulatory T cells and regulatory response. Mucosal immune response.
10. Immune response to the four type of pathogens: extracellular phagocytable (I), or non-phagocytable (IV), intracellular intraphagosomal (II), and intracellular cytoplasmic (III) pathogensActividades formativas
SESIONES:
M1. Clases magistrales: Exposición teórica de los contenidos de la asignatura por parte de un profesor, haciendo partícipes del aprendizaje a los alumnos.
M2. Complementos Magistrales: Exposición de trabajos del alumno, exposición teórica del profesor de contenidos complementario de la asignatura para favorecer el aprendizaje de los contenidos específicos.
TRABAJOS O WORKSHOPS:
M2. Complementos Magistrales: Exposición de trabajos del alumno, exposición teórica del profesor de contenidos complementario de la asignatura para favorecer el aprendizaje de los contenidos específicos.
M3. Seminarios: Talleres de trabajo en grupos de 3-4 alumnos que investigan retos propuestos por el profesor o textos relativos a la asignatura, los resumen y los exponen.
M4. Búsqueda de información: Fuentes originales, revisiones, Bases de datos, páginas web de la materia
M5. Aprendizaje basado en retos: La resolución de un reto, proyecto, caso seleccionado por el profesor con apoyo de apuntes, libros y herramientas informáticas en grupo
M6. Resolución de problemas: La resolución de ejercicios propuestos por el profesor con apoyo de apuntes, libros y herramientas informáticas en grupo
M8. Exposición: Exposición oral apoyado de herramientas electrónicas o físicas por parte del alumno de proyectos, trabajos, retos
M9. Debate dirigido: Discusión entre dos grupos de alumnos que se preparan diferentes Comparación de resultados diferentes de una investigación, que se preparan dos grupos de estudiantes y exponen, siendo espontáneo el desarrollo de la discusión. El objetivo es promover la expresión y comprensión oral de los estudiantes y desarrollar su sentido crítico.
PRÁCTICAS:
M13. Prácticas de laboratorio: Aprendizaje de técnicas de laboratorio, de aplicación de técnicas a la resolución de problemas, de desarrollo de protocolos, de interpretación de resultadosCronograma
Pulse sobre este enlace para obtener el cronograma detallado en excel
messages.programa_asignatura.Sesión: Número de orden dentro de la asignatura. Actividad formativa: MG Clase Magistral, SM Seminario, LB Laboratorios, TL Taller, PC Práctica Clínica, EV Evaluación.
Sesión |
Actividad |
Descripción |
Evaluación |
MG | 1 | INTRODUCTION Chapter: Immunology, one of the pillars for medicine | |
SM | 2 | Workshop: Books of Immunology / Other Universities´ Schedule | |
MG | 3 | Chapter 1. Introducction to the immune system. General features. | |
SM | 4 | Innate immunity diagram. | |
MG | 5 | Chapter 2. The pathogens. Comensal and infectous microorganisms. Microbioma | |
MG | 6 | Chapter 3. Goals, organ, tissues, cellular and molecular components of the innate immune system. PAMP. Nobel Prize 2010 | |
MG | 7 | Extra session: The organisms levels of organization: molecules, cells, tissues, organs, systems. | |
MG | 8 | Chapter 3b. Origin and maturation of cells of the innate immune system. Haematopoiesis and stem cells | |
SM | 9 | Workshop: Inflammation. Presentation express form disclosure articles. Is inflammation friend or foe? | |
MG | 10 | Chapter 4. Mechanisms of Innate immunity. Immflamation and anti-immflamatory drugs. | |
MG | 11 | Chapter 5. Adaptative immune system. Goals, organs, tissuse, cellular and molecular components of the adaptive immune system. | |
SM | 12 | Workshop: Coursera Personal Leadership Development Planning and Leading High Performing Teams | |
MG | 13 | Chapter 5b. Adaptative immune system. Secondary lymphoid organs and lymphatic system | |
MG | 14 | Chapter 6. Antigen processing and presentation to T cells. Dendritic cells and therapy. Nobel Prize 2010 | |
SM | 15 | Workshop: Medicina Nobel Prize 2010: Dendritic cells and RRP Toll like Receptors. Presentation express form disclosure articles. | |
MG | 16 | Chapter 6. Antigen processing … | |
MG | 17 | Extra session: Intracellular signaling in the innate immune system Introduction. Signal types: extracellular and cellular membrane. Ex:: Inflammosome, fagocytosis, cytotoxicity | |
MG | 18 | Chapter 7. HLA molecules, polymorphisms, and their role in transplantation. Cellular health surveillance | |
SM | 19 | Workshop: Immune system cells: Localization, function, molecules involved in those functions | |
MG | 20 | Review | |
MG | 21 | Continuous Asessment Exam | 0,75 |
SM | 22 | Workshop: Visulaize video: "Érase una vez el Cuerpo Humano: Centinelas del cuerpo". Find deffects and update. | |
MG | 23 | Chapter 8. Antigen receptors: BCR and TCR. Specificity and diversity. 1 in a hundred millions | |
MG | 24 | Presentation session: Poster exhibition and evaluation of a chosen subject in groups of 4. | 1 |
MG | 25 | Chapter 9. BCR and TCR genes and genetic reorganization. B cell and T cell maturation. Learning tolerance. Autoimmune diseases | |
SM | 26 | Exam revision. Kahoot | |
MG | 27 | Chapter 9. B cell and T cell maturation. Learning tolerance. Autoimmune diseases | |
MG | 28 | Chapter 10. Activation of T lymphocytes. Co-stimulatory molecules and biomedical applications. Vaccines | |
SM | 29 | Workshop: Presentation express of effector T cell differentaition and repsonse: Th1, Th2, ThF, Th17 or Treg . | |
MG | 30 | Chapter 11. T cell differentiation. Helper T cells effector responses. Enhance innate immunity in a special way | |
MG | 31 | Chapter 12. T cell differentiation. Cytotoxic T cells effector responses. Virus and tumours | |
SM | 32 | Cytokines: The most representative and their medical applications | |
MG | 33 | Chapter 13. Activation of B cells. Collaboration between T and B cells. Team work | |
MG | 34 | Extra session: Intracellular signaling in the adaptative immune system. Transcription factors in effector T cells. Immunotherapy targets. Signaling in effector cells. | |
MG | 35 | Chapter 14. Effector response: antibodies. Diagnosis, treatment and immunotherapy | |
SM | 36 | Workshop: Presentation express of effector B cells and antibodies | |
MG | 37 | Chapter 15. Immune response during reinfection. Memory response. Vaccines | |
SM | 38 | Workshop: How does memmory work. Vaccine efficiency | |
MG | 39 | Chapter 16. Lymphocyte tolerance. Regulatory T cells and regulatory response. Mucosal immune response. Containment and autoimmune diseases | |
MG | 40 | Presentation session: Poster exhibition and evaluation of a chosen subject in groups of 4. | 1 |
MG | 41 | Continuous Asessment Exam | 0,75 |
SM | 42 | Exam revision. Kahoot | |
MG | 43 | Chapter 17. Immune response to the four type of pathogens: extracellular phagocytable (I). Staphylococcus aureus and Mycobaerium tuberculosis | |
MG | 44 | Chapter 18. Immune response to the four type of pathogens: intracellular intraphagosomal (II). Mycobaerium tuberculosis | |
MG | 45 | Chapter 19. Immune response to the four type of pathogens: intracellular cytoplasmic (III) pathogens. Virus | |
SM | 46 | Workshop-Subtleness in the immune response. Similarities and differences between TH1, TH17, memory and tolerance | |
MG | 47 | Chapter 20. Immune response to the four type of pathogens: extracellular non-phagocytable (IV). Helminths | |
LB | 48 | Analysis of the complement activity | |
LB | 49 | Analysis of the complement activity | |
LB | 50 | Analysis of the complement activity | |
LB | 51 | Analysis of the presence of antibodies or anitgens by ELISA | |
LB | 52 | Analysis of the presence of antibodies or anitgens by ELISA | |
LB | 53 | Analysis of the presence of antibodies or anitgens by ELISA | |
LB | 54 | Leucocyte isolation and extraction from human blood | |
LB | 55 | Leucocyte isolation and extraction from human blood | |
LB | 56 | Leucocyte isolation and extraction from human blood | |
LB | 57 | Analysis of the presence of antibodies or anitgens by Immunofluoresence Assay | |
LB | 58 | Analysis of the presence of antibodies or anitgens by Immunofluoresence Assay | |
LB | 59 | Phagocytosis assay | |
LB | 60 | Exam | 1 |
Sistema y criterios de evaluación
The final qualification in January´s official announcement is the result of:
1) Continuous assessment
2) Final exam
1) The Continuous assessment includes:
a) First partial exams: 10%
b) Second partial exam: 7,5% (with notes and access to books)
c) Team work: 7,5%
d) Laboratory practices: 7,5%. Assistance to lab practices is compulsory for passing the subject
e) General assistance and participation in workshops: 7,5%
2) Final exam: 60%. It will be necessary to obtain a qualification of 5 or more to add the continuous assessment qualification.
No presentation to any of these assesments means a 0 in the qualification, only if the missatendance is justified the student must apply to the coordinator for an alternative exam before the evaluation date
The theory exams includes two parts: test exam with 4 different options (70%) and two descriptive questions (30%).
In June´s s official announcement a unique theory exam will be performed.
If a major motive impedes the atendance to this exam the student must write to medicinaexamen@uax.es previous to the date of the exam in order to apply for a new date.
Extraordinary exam:
The final qualification is the result of the exam alone: 100%Bibliografía
Básica:
1.- Olazabal I, Arias JA
Inmunología básica para medicina: 1ª Ed.: Elsevier
ISBN: 9788491133315
Complementaria:
2.- Abul Abbas Andrew Lichtman Shiv Pillai
Basic Immunology: Elsevier Saunders
ISBN: 9780323549431
3.- Fainboim L
Introducción a la Inmunología Humana: Panamericana
ISBN: 9789500602709